Nimtsovych T. High blood pressure variability in rural dwellers with arterial hypertension: clinical significance and approaches to management

The thesis deals with a new approach for solving the scientific and practical task in the field of knowledge 22 «Healthcare» (the specialty 222 «Medicine»), namely an improvement in the management of rural males with arterial hypertension (AH), by the study of clinically significant associations of visit-to-visit blood pressure variability (BPV) with cardiovascular risk factors (CVRF), AH-mediated target organs damage (TOD), non-valvular atrial fibrillation (AF), compliance with pharmacotherapy (CP), major adverse events (MAEs) at long-term follow-up, − and also by way of substantiation the approaches to pharmacological and non-pharmacological management of high BPV (HBPV) in rural hypertensives. The open prospective non-comparative study consecutively enrolled 160 rural males (mean age (50 ± 6,1) years) with primary AH of stage II (main group). Body mass index (BMI) was (median, interquartile range) 27,2 (24,8-30,2) kg/m2. The maximal AH degree was as follows: 1st– in 30 (18,8 %) patients; 2nd – 65 (40,6 %); 3rd – 65 (40,6 %). At enrollment, 85 (53,1 %) patients were current smokers. Seventy-seven (48,1 %) males pointed at alcohol consumption once a week and more. Paroxysmal AF was detected in 29 (18,1 %) patients.