Fedorenko O. Topographical and morphofunctional features of immune formations of rabbit intestine

In the dissertation the results of a complex research of topography and morphofunctional features of intestinal immune formations of domestic rabbit of white Panon breed at the age of four months are presented. For this aim modern macroscopic, histological, cytological, immunohistochemical and statistical methods were used. Rabbit intestinal immune formations are represented by Peyer's patches, sacculus rotundus in the ileum and appendix in the cecum. Male and female rabbits have a similar topography, shape and relief of intestinal immune formations. Peyer's patches are found only in the jejunum, ileum and cecum. They have a rounded and oval shape. In the jejunum males have 4-7 and females 4-5 Peyer's patches. There is a tendency to distance reduction between individual Peyer's patches the closer they are to the end of jejunum. Oval Peyer's patches located at the end of the jejunum are smaller compared to those at the beginning and in the middle of the jejunum. In the ileum there is mostly only one Peyer's patch. In the cecum we also found one Peyer's patch, one side of which borders with the ileal papilla and is located in the second haustra of the cecal base. The results, obtained in our study, complement the existing data on morphofunctional features of immune formations of domestic rabbit intestine. They can be used by scientists to study these structures in the ontogenesis of rabbits and other mammals. They can also be used by morphologists, physiologists and immunologists in the educational process in the study of hematopoietic and lymphoid organs of animals, as well as in the preparation of manuals, textbooks and reference books.