Markin O. The study of biologically active compounds of European mountain ash and development of herbal preparations on their basis

The thesis is devoted to the comprehensive study of biologically active compounds in European mountain ash leaves, fruits, flowers and bark; obtaining of herbal preparations from European mountain ash leaves, and development of normative documents on European mountain ash fruits and perspective herbal preparation from European mountain ash leaves. In European mountain ash leaves, fruits, flowers and bark, carbohydrates, organic acids, ascorbic acid, carotenoids, carboxylic acids, hydroxycinnamic acids, flavonoids, procyanidins, polyphenols, major and trace elements were determined; also terpenoids, aromatic compounds and heterocyclic compounds as volatile compounds were studied. Seven samples of European mountain ash fruits were studied according to the algorithm laid out in the instructions of the Pharmacopoeia Committee "Procedures for the elaboration of monographs on the herbal drugs for the introduction in the SPh Ukraine". As the results of the studies, the draft national monograph "Sorbi fructusN" was developed and it was recommended by the SE "Ukrainian Scientific Pharmacopoeia Centre for Quality of Medicinal Products" for the introduction in the SPh Ukraine 2.5. The effects of thick extracts "Sorbafol" and "Phenogor" on glucose metabolism and the excretory renal function in rats were first studied. The novelty of the research was confirmed by the utility model patent of Ukraine "Therapeutic and prophylactic preparation with hypoglycaemic effect from European mountain ash leaves" (No. 133831, Bull. No. 8 of 25.04.2019), and the invention patent of Ukraine "Therapeutic and prophylactic preparation with hypoglycaemic effect from European mountain ash leaves" (No. 122521, Bull. No. 22 of 25.11.2020). Based on the results of the research, the DQCM project for "European mountain ash leaves thick extract "Sorbafol" was first developed.