Myha M. The pharmacognostic study of some Salvia L. genus species of the flora of Ukraine for creating new medicines

The thesis is devoted to the pharmacognostic study of the raw material of Salvia L. (sage) genus promising species of the Ukrainian flora, development of methods for obtaining extracts, their phytochemical and pharmacological study, determination of parameters for standardization of the promising species leaves and the most promising substances based on them. The study of the morphological and anatomical structure of promising Salvia L. genus species leaves of the Ukrainian flora was performed. In all samples of S. officinalis, S. grandiflora, S. pratensis and S. verticillata leaves studied the content of macro- and microelements, aminoacids, phenolic compounds, saponins and volatile compounds. For S. grandiflora and S. verticillata leaves, as the most promising types of raw materials, the QCM drafts were developed. From the studied raw materials, methods for obtaining new extracts with anti-inflammatory activity were developed and their phytochemical and pharmacological research was carried out. It was found that the most promising substance is the dry extract from the S. officinalis leaves, modified with L-lysine. The QCM drafts «S. officinalis leaves dry modified extract» was developed.