The thesis focuses on the theoretical generalization and new solution of the topical issue of internal medicine – diagnosis effectiveness of patients with stage ІІ hypertension of 1-3 degrees, combined with connective tissue dysplasia (CTD), based on studying of external and internal signs of CTD, indicators of nonspecific systemic inflammation (C-reactive protein (CRP), seromucoid (SM), interleukins (IL) -1 beta (1β), IL-6, IL-8, tumor necrosis factor-alpha (TNF-α)), free and total blood oxyproline, blood lipid spectrum, uric acid (UA), the results of instrumental research methods, consultations of specialists and development of an algorithm for assessing the risk of developing hypertension in the presence of CTD. The objectives of the research were to increase the effectiveness of diagnosis of patients with stage ІІ hypertension, 1-3 degrees, combined with CTD, based on the study of CTD external and internal signs, to investigate indicators of nonspecific systemic inflammation (CRP, SM, IL-1β, IL-6, IL- 8 and TNF-α), to analyze the indicators of free and total oxyproline in the blood, the blood lipid spectrum and the level of UA, to evaluate the results of blood pressure daily monitoring (DBPM), to develop an algorithm for assessing the risk of hypertension. In accordance with the objectives, the study included 100 patients with stage ІІ hypertension of 1-3 degrees, combined with CTD, and 30 people without the high blood pressure and established CTD, who voluntarily agreed to participate in the research. For the first time, the new scientific results of hypertension combined with CTD clinical course peculiarities are being received. Moreover, for the first time, the degree of connective tissue (CT) lesions severity was assessed based on studying the external and internal signs of CTD and its influence on the course of hypertension. It was found that the increased level of CRP in patients with stage II hypertension of 1-3 degrees, combined with CTD, can be regarded as an additional predictor of progression of hypertension and, consequently, the occurrence of cardiovascular complications. An increase in the content of IL-8 in the blood was observed, which reflects the presence of an inflammatory process in the CT, as well as an increase in the level of SM, which indicates the chronic nature of inflammation. For the first time, an increase in the concentration of free oxyproline in the blood of patients with stage II hypertension of 1-3 degrees, combined with CTD, which reflects the degree of collagen breakdown (a process characteristic of CTD), was found. An increase in the concentration of total oxyproline was observed, which indicates an increase in collagen metabolism in the presence of an inflammatory process in the CT. For the first time, an increase in the blood of patients with stage II hypertension of 1-3 degrees, combined with CTD, levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL cholesterol), atherogenic factor (AF) and a decrease in high-density lipoprotein cholesterol (HDL cholesterol) was found. Moreover, for the first time, an increase in the level of UA in this cohort of patients was noted, which indicates the presence of additional risk factor (RF) of cardiovascular complications. Scientific data on the use of DBPM in patients with hypertension in the presence of CTD, which is necessary to diagnose and optimize the management of such patients, as well as to provide more informative monitoring of the disease were updated. For the first time, a score scale for assessing each of the signs of CTD and an algorithm for the risk of hypertension in the presence of CTD, taking into account the degree of hypertension were developed.
