Sych V. The role of tachykinins in inflammatory blood system reactions.

Inflammation is a typical pathological process, which is the basis of most human diseases, a topical problem of medicine. It is the series of sequential intercellular interactions that are regulated by mediators – modulators of inflammation. Of considerable interest is the question of the role of tachykinins, namely substance P and neurokinins in the pathogenesis of inflammation, which is still insufficiently studied. Among all the regulatory peptides involved in the formation of neurogenic inflammation, substance P and neurokinins are of particular interest. Substance P, except for the nervous system, where it is present in the cerebral cortex, reticular formation, substantia nigra, cerebellum, hypothalamus, spinal cord, is found in almost all tissues of the body as part of sensitive neurons, peripheral nerves and apudocytes. The presence of substance P receptors on mast cells, polynuclear cells, macrophages and keratocytes has been proved. It was found that neuropeptide receptors were found on the cells of bone marrow origin, peripheral blood lymphocytes and monocytes. Neuropeptides increase vascular permeability, intensify the adhesion of neutrophils to the venular endothelium, increase the sensitivity of nociceptors, participate in the formation of inflammatory pain. A special criterion for the presence of the type, course of inflammation, effectiveness of anti-inflammatory medications and appropriate therapy is the cellular dynamics of the inflammatory focus and interrelated changes in all the blood system, as well as studying the course of inflammation under blockade or stimulation of substance P and neurokinins, can give integrative answers on the role and receptor mechanisms of tachykinins in the pathogenesis of inflammation. A special criterion for the presence of the type, course of inflammation, effectiveness of anti-inflammatory medications and appropriate therapy is the cellular dynamics of the inflammatory focus and interrelated changes in all the blood system, as well as studying the course of inflammation under blockade or stimulation of substance P and neurokinins, can give integrative answers on the role and receptor mechanisms of tachykinins in the pathogenesis of inflammation.