Object. Anterior and intermediate non-infectious uveitis. Purpose. To increase the efficiency of diagnostics of the activity grade of the inflammatory process in non-infectious anterior and intermediate uveitis in the experiment by determining temperature changes of the eye surface in the projection of the ciliary body. Methods. Thermometry of the ocular surface in the projection of the pars plana by using a thermoelectric device, which allows to make measurements with high accuracy (temperature ranges from -10° C to + 120° C with a measurement error ± 0.08° C), biomicroscopy by using a slit lamp, ophthalmoscopy with a slit lamp and noncontact lens 90D, assessment of the inflammatory reaction degree by using the developed scoring system of criteria, anterior segment of the eye color photography, histomorphological studies of animal eyes, statistical methods. Scientific novelty. The knowledge of the temperature of the rabbit eye was enhanced. It was established that the surface temperature of right and left eyes in the projection of the ciliary body in rabbits, in the absence of pathological changes, does not differ significantly. The average eye surface temperature in the projection of the ciliary body in intact rabbits was 34.1°C (SD=1.4). First established that at the first day of the development of induced non-infectious anterior and intermediate uveitis – there is a significant increase in temperature in the projection of the ciliary body both affected eyes to 35.7°C (p=0.002) and fellow eyes to 35.0°C (p=0,05) compared to intact rabbits, which is not accompanied by any histomorphological pathological changes of the fellow eye and is functional in nature. The fifth day – there is a significant difference in surface temperature of affected eyes - 36.0°C and fellow eyes - 34.7°C (p=0.04). Scientific knowledge on correlation of the temperature of the ocular surface in the projection of the ciliary body with clinical picture of the rabbit eye with induced non-infectious anterior and intermediate uveitis has been enhanced. The significant correlation (р<0,05) was found between the surface temperature of the affected eye and the clinical inflammatory signs (except hypopyon). The difference in temperature between the affected eye and the intact eye correlated with the weighted score of clinical signs of experimental uveitis activity. Thus, this correlation was strong (r=0.73; р=0.008) on day 1, became weaker on subsequent days and became not significant from day 8 (r=0,4; р=0,19). Scientific knowledge on the histomorphological condition of the rabbit eye with induced non-infectious anterior and intermediate uveitis depending on the temperature of the ocular surface in the projection of the ciliary body has been enhanced. After clinical disappearance of signs of active anterior uveitis, but with elevated surface temperature of the affected eye, signs of active intermediate uveitis are determined; the ciliary body is in the exudative-emigration phase of inflammation, and the normalization of the surface temperature of the affected eye in the projection of the ciliary body in rabbits with modeled non-infectious anterior and intermediate uveitis occurs in the phase of proliferation and completion of the inflammatory process. Practical value. As a result of this work, the usage of a simple and accessible method of contact measurement of the ocular surface temperature in the projection of the ciliary body in anterior and middle uveitis in rabbits was found, suitable for objective determination of the activity of this pathological process. And the control of ocular surface temperature in the projection of the ciliary body in induced non-infectious anterior and intermediate uveitis in rabbits can be used to determine the phase of the inflammatory process in studies on this model. The results of the work were introduced into the scientific practice of Inflammatory eye pathology division of the State institution “The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine”, Odesa; laboratory of pathomorphology and electron microscopic research of the State institution “The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine”, Odesa. Scope. Medicine, ophthalmology.
