Chernetska S. Theoretical and experimental substantiation of the composition and technology of phytosubstance of oregano and tablets based on it

The data of literature sources on the problems and methods of treatment of throat diseases in Ukraine and in the world are processed and generalized. The composition, technology and methods of analysis of oregano dry extract were scientifically substantiated and experimentally confirmed. Its anti-inflammatory activity and antimicrobial properties have been established. The novelty of the research is confirmed by the patent of Ukraine for the utility model «Method of obtaining a herbal substance with anti-inflammatory and antimicrobial action» № 142304 (25.05.2020.). The optimum structure and technology of tablets for application in an oral cavity have been theoretically and experimentally substantiated on the basis of complex pharmaco-technological and physico-chemical researches and using methods of mathematical planning of experiment, their antimicrobial activity has been confirmed; quality indicators of the developed tablets are investigated, the conditions and term of their storage have been established. Oregano dry extract with bacteriostatic and anti-inflammatory action has been developed and proposed for practical pharmacy. Projects of quality control methods and technological rule have been developed and tested in the conditions of production of Ternopharm LLC. Tablets based on the dry extract with bacteriostatic and anti-inflammatory action for the treatment of throat diseases have been developed and proposed for the practical pharmacy. The research results have been introduced into the educational and scientific process in the training of pharmaceutical specialists in higher education institutions of pharmaceutical profile of Ukraine.