Zemliana N. Improving the diagnosis and prediction of hyperplastic processes of the endometrium based on the study of individual markers of oncogenesis

The dissertation is devoted to improvement of methods of diagnostics and development of methods of forecasting of a course of hyperplastic processes of an endometrium (HPE) on the basis of research of separate markers of oncogenesis. The study consisted of two stages. In the first stage, 147 women with various forms of endometrial hyperplastic processes and adenocarcinoma with or without uterine fibroids aged 24 to 65 years (average - 42.3 ± 1.23 years) were examined. Patients were divided into 3 groups depending on the specific form of endometrial pathology. The first group included 54 patients with simple endometrial hyperplasia without atypia (SEHWA) (mean age 41.6 ± 1.31 years). The second group consisted of 67 patients with complex endometrial hyperplasia without atypia (CEHWA) (mean age 40.9 ± 1.34 years). The groups were divided into subgroups depending on the presence of uterine fibroids. The third group included 26 patients with endometrial adenocarcinoma (mean age 43.59 ± 1.43 years). The control group consisted of 20 people without gynecological pathology. In the second stage, the predictor significance of clinical-anamnestic and molecular-biological parameters was assessed for patients with SEHWA (48 patients) and CEHWA (73 patients) involved in the study, and observations were performed during the year. One year after enrollment, all patients underwent a repeat ultrasound of the pelvic organs to detect recurrence of HPE. When performing repeated ultrasound of the pelvic organs, the thickness of the endometrium was assessed to assess the occurrence of recurrences.