The object of the study was the course of pathological changes in the internal organs of rats on the background of experimental ulcerogenesis induced by nonsteroidal anti-inflammatory drugs.
The aim of the study was to establish the effect of placental cryoextract on ulcerogenic action and therapeutic efficiency of nonsteroidal anti-inflammatory drugs.
Research methods and equipment were as follows: pathophysiological, oncometric, planimetric, macroscopic, pathomorphological and immune histochemical, hematological and biochemical, statistical. The studies were performed using an electrical stimulator of the laboratory "ESL-2", mechanical strain gauge "Paw Pressure Analgesia Meter DAQ 37215" (Ugo Basile, Italy), disability tester ("Linton Instrumentation", UK), automated hemanalyst, cryodevice "Cryo Max" (Cortex Technology, Denmark) and inverted microscope (Meiji Techno, Japan).
Results and their novelty –the presence of antiulcer activity in cryopreserved placenta extract was for the first time established, which against the background of prophylactic administration in the model of acute indomethacin-induced gastric injury was 69.1%; in the model of acute diclofenac sodium-induced damage it made 92.1%. Under the treatment regimen in rats with subchronic meloxicam-induced gastropathy, the antiulcer activity was 100%. Under the treatment-and-prophylactic regimen, the antiulcer activity of cryopreserved placenta extract in models of subchronic ibuprofen-induced and acetylsalicylic acid-induced gastric damage was 72.8% and 70.6%, respectively. The mechanisms of antiulcer activity of placental cryoextract on the background of experimental rheumatoid arthritis were established for the first time. The influence of placental cryoextract on the functional state of the gastrointestinal tract, apoptosis of gastric epitheliocytes associated with nonsteroidal anti-inflammatory drugs. For the first time, scientific data on the modification of anti-inflammatory and analgesic activity of nonsteroidal anti-inflammatory drugs under the influence of cryopreserved placenta extract in their combined use were obtained. New data on the mechanisms of anti-inflammatory activity of cryopreserved placenta extract and nonsteroidal anti-inflammatory drugs when they used in combination have been obtained.
Degree of implementation – 33 scientific papers have been published.
Field of application – cryomedicine, pharmacology, gastroenterology, rheumatology.
