Sheremeta B. Structural and functional factors in formation of concentric remodeling of the left ventricle in practically healthy young normotensive individuals

The study was conducted in 2 stages. The first stage included 420 healthy young people (18-44 years) who underwent echocardiography for various reasons. In the second stage, the study included 38 people with CRL and 38 people from the control group. The results of the assessment of cardiac structures indicate the presence of small structural abnormalities (MCA) in a number of subjects of all groups. Further comparative analysis revealed differences in the values of daily blood pressure monitoring. Further comparative analysis of the state of the autonomic nervous system (ANS) showed that against the background of almost identical indicators of the sympathetic link ANS (LF), in the group with CRL was significantly lower than the parasympathetic link. According to HMEKG, people with CRL had a relatively smaller nocturnal decrease in heart rate, which was reflected in a lower circadian index. In addition, patients with CRL had a significantly higher number of supraventricular. Analysis of the daily EC profile clearly demonstrated the advantage of the night distribution. A comparative analysis of the Doppler study of the structural and functional state of the common carotid arteries (CSA) revealed a significant increase in deceleration time, which clearly indicated a decrease in the relaxation of the carotid arteries and indirectly indicates a decrease in the elasticity of the common carotid vessels. In parallel with the changes in the USA, an increase in the cross-sectional plane of the internal jugular veins in persons with CRL was determined, which indicated a certain venous stasis, which was associated with a deterioration in the elastic properties of the carotid arteries. These changes reflected early vascular wall remodeling in patients with concentric left ventricular remodeling. In a multiple step-by-step analysis of independent predictors of concentric LV remodeling in healthy individuals, those factors that had a significant (p <0.05) linear regression relationship with CRL were considered as independent predictors (NP). Combinations of independent predictors have been identified that have made it possible to significantly increase the chances of a priori prediction of concentric remodeling in healthy individuals. The use of these parameters in the examination of young people improves the early diagnosis of heart disease in the absence of complaints and classical criteria for the diagnosis of cardiovascular disease, especially - masked hypertension.