Matokhnyuk M. Cardiotrophin-1 gene polymorphism in men with essential hypertension complicated by chronic heart failure. Diagnostic and clinical significance

As a result of the study, data were obtained that in the group of males 40-60 years old, patients with EH of varying severity, carriers pool of genotypes GA + AA of the CT-1 gene are significantly more common, the same results were obtained in men with CHF. It was determined that the carriers of the variant GA + AA genotypes of the CT-1 gene in men with LVH and CHF on the background of essential hypertension have higher levels of plasma concentration of CT-1 than in the carriers of the GG genotype. Patients with EH stage ІІ of carriers of the GA + AA variant of the CT-1 gene had significantly more frequently burdened heredity for this disease. With the help of roc - analysis, the limit levels of CT-1 in blood plasma for early diagnosis of LVH and the development of CHF in men with EH of varying severity were calculated: the limit level of CT-1 in blood plasma is higher - ≥ 122 pg / ml (sensitivity-95%, specificity-100%), can be used for early diagnosis of such myocardial changes as LVH, and the cut-off level - ≥ 303 pg / ml (sensitivity – 86 %, specificity - 92%) for screening diagnosis of EH complicated in the form of CHF. It was determined that the carrier of GA + AA genotypes of the CT-1 gene in patients with EH stage ІІ and EH complicated CHF is associated with higher LV size and volume at the end of systole and diastole, revealed a positive correlation of CT-1 in blood plasma with the values of LV size in individuals with EH ІІ, the same data were obtained in individuals with CHF. A list of phenotypic features of the patient's portrait has been formed, which can be used to predict the course of essential hypertension. A method has been developed with the help of discriminant analysis, which can also be used to detect an unfavorable prognosis of the disease.