Grabchak S. Features of remodeling of the vascular bed and the wall of the duodenum in obstructive cholestasis and its correction

The dissertation is devoted to the study of the state of structural and spatial organization of the circulatory vascular bed of the duodenum in laboratory adult male pigs in the conditions of experimental obstructive cholestasis and different types of its correction. With the help of a set of morphofunctional methods the morphogenesis of the vascular bed of the duodenum depending on different terms of obstructive cholestasis was studied. Objective histological, electron microscopic, macro- and micromorphometric and functional criteria of adaptive-compensatory processes of a vascular bed of a duodenum in the conditions of the created experimental pathology are established, degrees of their reversibility in various terms of obstructive cholestasis are defined. It is determined that the combined use of enterosorbents together with choledochoduodenostomy creates the most optimal conditions for the development of adaptive-compensatory processes in the vascular bed of the duodenum due to the elimination of obstructive cholestasis.