Storozhuk N. Components of hemostasis as predictors of restenosis in patients with CAD and Percutaneous Coronary Angioplasty

The incidence of late stent restenosis in patients with CAD after angioplasty was found to be 2,37 % within 18-month of follow-up, while restenosis was significantly more common in patients with heart failure HF IIA (75,0%) (p < 0,001) and in those with two or more stents (56,3 %) (p < 0,001). Significantly increased level of soluble fibrin was found in study patients as compared to the control (4,67 ± 0,25 versus 2,65 ± 0.37 μg/ml) (p < 0,001) along with twofold decrease in D-dimer concentration (48,44 ± 4,87 versus 95,0 ± 12,0 ng/ml) (p < 0,001). At the same time, concentration of D-dimer in women tended to decrease as compared to that in men. The patients with history of restenosis had significantly higher level of soluble fibrin than those with no stent occlusion (5,71 ± 0,50 versus 4,11 ± 0,33 μg/ml) (p < 0,05) along with elevated fibrinogen concentration as compared to the control (p < 0,001), significantly reduced D-dimer level (p < 0,001) and the tendency to decrease of protein C concentration. Moderate direct correlation between soluble fibrin and D-dimer (r = 0,54), and weak direct relationship between soluble fibrin and fibrinogen (r = 0,26) was demonstrated along with significant increase in the level of functionally inactive forms of prothrombin by 113,1 ± 2,39 % as compared to the control (p < 0,001), corresponding to concentration of 1,2 μg/ml and having moderate direct relationship with D-dimer level (r = 0,36).