Lysokon Y. Optimization of conservative treatment of destructive forms of apical periodontitis using bone-plastic material

The dissertation is devoted to clinical and experimental substantiation of the choice of method and means for treatment of patients with destructive forms of apical periodontitis, based on experimental substantiation of drug selection with osteotropic properties for correction of inflammatory – destructive process in periapical tissues. In the experiment, the osteotropic effect of various drugs and their combinations has been studied. The means and method of obturation of the apical area with a therapeutic composition and its transcanal removal outside the apex of the tooth root have been developed. Based on the results of clinical, radiological, histological, densitometric studies, a comparative assessment of the intensity of regenerative processes in the bone tissue of experimental animals has been made under the action of the proposed osteotropic drugs. A comprehensive clinical, radiological, densitometric evaluation of the short-term and long-term results of the development of the developed composition for the treatment of patients with has been of destructive forms of apical periodontitis made. A computer program of osteometry has been used, which allowed to objectify the results of treatment. It is proved that the use of the drug "mp3 OsteoBiol" in combination with autologous platelet-rich plasma causes rapid and complete reduction of the periapical focus of destruction by optimizing reparative processes. Reduction of treatment time with the use of the proposed composition is achieved due to the simultaneous replacement of the bone defect of the periapical area, including the significant size of the destructive focus. Developed 3-D tip for apical obturation and additional transcanal output of the proposed composition in the periapical zone, which significantly reduced the zone of inflammatory-destructive changes in the surrounding apical tissues.