Savchyn S. Rationale for the prevention of dental diseases in children with infectious mononucleosis. – Qualifying scientific work as a manuscript.

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0824U001209

Applicant for

Specialization

  • 221 - Стоматологія

23-02-2024

Specialized Academic Board

ДФ 35.600.095 (ID4585)

Danylo Halytsky Lviv National Medical University

Essay

The dissertation is devoted to improving the effectiveness of the prevention of dental diseases in children with infectious mononucleosis. The obtained results of clinical, immunological and microbiological studies made it possible to substantiate a complex of treatment and prevention measures for the main dental diseases in children with infectious mononucleosis. To assess the incidence of infectious mononucleosis in children, 448 medical records (No. 003/0) of children who were hospitalized and treated at the Lviv Regional Infectious Disease Hospital for the period from 2019 to 2022 were retrospectively analyzed. It was established that 61.83% of hospitalized children were boys and 38.17% were girls. During all years, the predominance of boys hospitalized with IM was determined. Children from 1 to 5 years old were hospitalized much more often (60.26%). The main symptom complex in children was tonsillitis, lymphadenopathy, weakness, hyperthermia, plaque on the tongue.On the basis of the clinical examination of 48 children with infectious mononucleosis aged 6-9 years, it was established that the prevalence of caries of temporary teeth in the examined children, on average, is 87.53±2.34% with an intensity of lesion 6.13±0.58 of a tooth but among children without signs of viral infection the result is: 76.15±2.13% (p<0.001) with the intensity of lesion 4.81±0.53 of a tooth (p>0.05). When studying the activity of the carious process, on average, 20.94±2.58% of children with infectious mononucleosis had the 1st degree of caries activity, in the control group of such children it was 32.30% more (36.29±2.31%, p<0.05). II and III degrees of caries activity were more often detected in children of the main group (50.22±3.24% and 21.23±1.45%) compared to children of the control group (42.47±2.13% and 13.90± 0.89%, p<0.05). The analysis of the results of the examination of children with infectious mononucleosis aged 6-14 years showed that the prevalence of caries of permanent teeth in the examined children with this pathology, on average, is 73.68±3.04% with the intensity of the lesion of 3.41±0.24 of a tooth, while among children without signs of viral infection - 65.06±2.98% with the intensity of lesion of 2.53±0.22 of a tooth (p1<0.05, p2<0.01). When analyzing the activity of the caries process, it was found that the first degree of caries activity was found significantly more often in children of the control group (29.19±3.31%) in relation to children of the main group (17.33±3.68%, p<0.05 ). On the other hand, among children with infectious mononucleosis, the proportion of individuals with the II degree of caries activity was, on average, 10.04% higher than among practically healthy ones (31.87±3.24% versus 28.96±3.13 of a tooth, respectively, p>0.05). III degree of caries activity was diagnosed 5.55 times more often among children compared to the control group (p<0.05) .A comparative assessment of the state of periodontal tissues was carried out in 66 children aged 9 and 12 with infectious mononucleosis and in 117 somatically healthy children of the same age (control group). Phenomena of the inflammatory process in the periodontal tissues in the form of chronic catarrhal and hypertrophic gingivitis in children with infectious mononucleosis, on average, were detected in 69.70±5.66%, which corresponds to a high level according to WHO criteria and occur much more often in relation to children of the control group (48.72±4.62%, p<0.01), which corresponds to the average level. Among children with infectious mononucleosis, chronic catarrhal gingivitis (CCG) was diagnosed in 63.64±5.92% of cases, which is 40.49% more often than in the control group (45.30±4.60%, p<0.05). The number of children with hypertrophic gingivitis against the background of infectious mononucleosis was 77.19% higher than in children of the control group. When analyzing the severity of CCG, it was established that in children with infectious mononucleosis, on average, the mild severity is 52.38 ± 7.71 % against 81.13 ± 5.37% in the control group (р<0.01). The proportion of children in the main group with a moderate severity of CCG was significantly higher (42.86 ± 7.64%) compared to children in the control group (18.87 ± 5.37%, p<0.05). Severe severity was diagnosed only in 4.76 ± 2.29% of cases in children with infectious mononucleosis, but a severe form of CCG was not detected at all among somatically healthy children. In order to study the prevalence and structure of dentoalveolar anomalies, we examined 183 children aged 9 and 12 years (66 children with a history of infectious

Research papers

Смоляр Н.I., Чухрай Н.Л. , Савчин С.В. Епштейна- Барр вірусна інфекція у дітей // Вісник.Українська медична стоматологічна академія . 2019. №1. C43-47. DOI: Доступно: https://visnyk-umsa.com.ua/index.php/journal/article/view/36/34

Чухрай Н.Л., Безвушко Е.В., Савчин С.В., Семенців Х.В., Шпотюк О.О. Особливості перебігу карієсу тимчасових зубів у дітей з Епштейн -Барр вірусною інфекцією // Буковинський медичний вісник. 2020. № 3. С. 157-164. DOI: https://doi.org/10.24061/2413-0737.XXIV.3.95.2020.87 Доступно:

Чухрай Н.Л., Савчин С.В. Поширеність зубощелепних аномалій у дітей із мононуклеозом// Вісник стоматології. 2022. № 1. С. 67-70. DOI: https://doi.org/10.35220/2078-8916-2022-43-1.12 Доступно:

Савчин С.В., Дубецька-Грабоус І.С. Лесіцький М. Ю. Особливості перебігу карієсу постійних зубів у дітей із вірусною інфекцією Епштейна- Барр. // Клінічна стоматологія. 2020. № 3. С. 63-70. DOI: DOI 10.11603/2311-9624.2020.3.11572

Чухрай Н.Л., Савчин С.В. Стоматологічний рівень здоров’я дітей, які перехворіли на інфекційний мононуклеоз.// Український стоматологічний альманах. 2023. №3. С. 85-90. DOI: Доступно: https://dental-almanac.org/index.php/journal/article/view/622/616

Чухрай Н.Л., Савчин С.В., Дубецька-Грабоус І.С. Поширеність зубо-щелепних аномалій у дітей з інфекціним мононуклеозом. // Актуальні питання сучасної стоматології”. 2021. С. 204-206.

Dental health of children with infectious mononucleosis/ Chukhray N., Mashkarynets O., Savchyn S, [et al.] // Miedzynarodowa Konferenja Naukowo -Szkoleniowa Lekarzy Dentystow. 2023. P.32

Рrevalence and features of malocclusions in children with persistent Epstein-Barr virus infection / Chukhray N., Savchyn S., Musij- Sementsiv Kh., Mashkarynets O. et al. // Miedzynarodowa Konferenja Naukowo -Szkoleniowa Lekarzy Dentystow. 2023. P.41

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