Poberezhets V. Chronic obstructive pulmonary disease in combination with skeletal muscle dysfunction: clinical and functional features and individualization of treatment. – Qualifying scientific work on the rights of manuscript

We discovered that the prevalence of skeletal muscle dysfunction (SMD) among patients with chronic obstructive pulmonary disease (COPD) was 25,3 % based on the examination of 190 patients with COPD. For the first time, it was found that the course of COPD in patients with concomitant SMD is characterized by an increased frequency of acute exacerbations, more intensive symptoms of COPD, a significant decrease in respiratory function, worsening the prognosis, reduced quality of life. For the first time, it was found that the risk of SMD is associated with higher age and lower body mass index. The risk of decreased skeletal muscle endurance is associated with a high Charlson comorbidity index, high intensity of dyspnea and severe bronchial obstruction. For the first time, we found out that adherence to triple inhaled therapy of COPD is associated with severe bronchial obstruction and intensive SMD. For the first time, it was found that the implementation of a personalized eight-week program tailored to the severity of SMD and COPD severity is safe and can significantly reduce the intensity of COPD symptoms. The adherence to home-based pulmonary rehabilitation among patients with COPD is low. Refusal to perform pulmonary rehabilitation is associated with intensive COPD symptoms. Premature discontinuation of pulmonary rehabilitation is associated with decreased lung function, skeletal muscle strength and muscle size.