Shchurko M. Pathogenesis of immune dysfunction in the setting of metabolic syndrome in coronary heart disease.

The dissertation studies the pathogenesis of coronary heart disease in the setting of the metabolic syndrome. It also identifies the pathogenic role of the immune system in coronary heart disease in the setting of the metabolic syndrome. The objectives of the study were: to determine indicators of the hormonal, lipid, carbohydrate spectrum of blood serum, indicators of cellular and humoral immunity, markers of inflammation, and to study cytokine dysfunction, correlations of the studied indicators in coronary heart disease (CHD) in the setting of metabolic syndrome. The object of the study was ischemic heart disorders in combination with metabolic syndrome. The subject of the study is the identification of markers associated with cardiovascular risk. Applied methods: biochemical, immunoenzymatic, immunological, statistical. 150 patients were selected for the study at the Department of Family Medicine of the Communal City Clinical Emergency Medical Hospital of Lviv. Patients were chosen based on their clinical data and age. They were all over 47 years old (mean age (56.17 ± 4.12) years), and 68.4% of them were men. 60 patients had verified coronary heart disease (CHD) without metabolic syndrome - group 1, the other 60 patients had verified CHD with metabolic syndrome - group 2. The obtained laboratory indicators were compared with the control group of 30 practically healthy individuals, which included male and female aged 47 to 67 years without accompanying pathology. They were donors of Lviv Communal City Clinical Hospital of Emergency Medical assistance transfusion department.