Oliinyk Y. Mechanisms of damage and regeneration of the liver and kidneys tissue at the rats in conditions of chronic toxic lesions by carbon tetrachloride and ethanol, ways of correction

The experiments were performed on 96 white non-linear sexually immature female rats weighting 60-80 g. The animals were divided into four groups: group 1 – intact rats; group 2 – animals with chronic toxic hepatitis, induced by intragastric injection of 20% oily solution of tetrachloromethane in the dose of 0.1 ml/100 g of body weight twice a week combined with 5% ethanol solution for 8 weeks; group 3 and group 4 - animals with chronic toxic hepatitis, treated for 8 weeks with intragastrically administered lisinopril (20 mg/kg/day) and reference drug L-arginine L-glutamate (35mg/kg/day), respectively. The study has provided additional data as to the mechanisms of damage and regeneration of liver and kidney tissues under the action of tetrachloromethane and ethanol toxicants and using correction with lisinopril and reference drug L-arginine L-glutamate, namely, the role of signaling systems associated with TGF cytokines -β and IGF-1has been clarified. Besides, the use of lisinopril to correct liver and kidney damage in case of chronic tetrachloromethane and ethanol intoxication has been proven from pathogenetic and morphologic point of view. The results obtained in the study could serve the theoretical basis for further clinical studies which would lead to improvement of pathogenetic therapy of chronic toxic lesions of liver and kidneys.