Yuryk Y. Morphophynctional features of heart remodeling according to postcompression period of crush syndrome

The dissertation provides of comprehensive study of the structural and functional features of reparative remodeling of the heart in the postcompression period of crush syndrome (CS). With a purpose confirmation of the important role of stress under the conditions of CS development in the experiment the dynamics of changes in cortisol concentration in blood serum were studied experimental animals, morphological study was carried out adrenal glands, secretory activity of myoendocrynocytes and mathematical analysis of heart rate variability in the postcompression period of CS. Massometric and planimetric researches ventricles of the heart were conducted and were described adaptative and compensatory processes of the heart muscle in the early, intermediate and late postcompression periods of CS. A complex of light-optical, polarizing and submicroscopic microscopy describes the structural and morphological reorganization of the myocardium and of the bloodstream in the dynamics of development of the postcompression period of CS. Identified 3 stages, that reflect features structural remodeling of the heart in the postcompression period of CS: 1) stress-induced, alterative – in the early postcompression period (1–3 days); 2) adaptive-compensatory, – in the intermediate (7 days); 3) reparative remodeling – in the late period of CS through 14 days of study. It was established that in the early postcmpression period of CS, the activation of the sympathetic link of the autonomic nervous system prevails in the regulation of the contractile work of the heart, and in the intermediate and late periods after decompression, there is a gradual restoration of autonomic balance. The predominance in the stage of alterative processes was established through 1 day after decompression of experimental rats hyperplasia of mature and diffusing secretory granules, what is a morphological manifestation of accumulation and secretion of atrial natriuretic hormone and a significant decrease number of secretory granules after 3 days of study, what can be considered a manifestation of the structuralal reaction of endocrine cardiomyocytes to compression stress. In the stage of compensatory reparative remodeling takes place restoration of the structure and function secretory myoendocrine cells.