Matar M. Study of bearberry (Arctostaphylos uva-ursi) extracts with the addition of amino acids antidiabetic effect

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0823U100635

Thesis Registration Form

0823U100635.pdf

Applicant for

Mazen F. Matar

Specialization

226 - Фармація, промислова фармація

Date of defense

07-09-2023

Specialized Academic Board

ДФ 64.605.062_1969

National University of Pharmacy

Essay

The thesis is devoted to the experimental study of hypoglycemic, antioxidant, hepatoprotective and lipotropic activity of the bearberry (Arctostaphylos uva-ursi), leaf extracts without and with the addition of amino acids, for the correction of insulin resistance and, accordingly, as promising components of the complex therapy of type 2 diabetes mellitus. Phytotherapy becomes an important part of the treatment and prevention of metabolic disorders. Herbal remedies can be used at certain stages of type 2 diabetes as monotherapy in combination with diet therapy, as well as in combination with hypoglycemic drugs. For the first time, the study substantiated and experimentally proved the expediency of using of bearberry leaf dry extracts with the addition of amino acids to create new effective and safe antihyperglycemic medications for the correction of insulin resistance and in the complex therapy of type 2 diabetes

Thesis supervisor

Ganna B. Kravchenko

Official opponents

Liudmyla S. Fira
Tamara I. Iermolenko

Reviewers

Victoria A. Rybak
Liudmyla V. Derymedvid

Research papers

Kravchenko G. B., Mazen M., Krasilnikova O. A. Screening of Bearberry leaves extracts hypoglycemic effect and study of acute toxicity. Ukrainian biopharmaceutical journal. 2018. 2 (55), 13-16.

ravchenko G.B., Krasilnikova O.A., Mazen M. Study of bearberry leaves extracts hypoglycemic action under experimental insulin resistance in rats. Клінічна фармація. 2020. Т.24, № 3. С. 54-57.

Kravchenko G.B., Krasilnikova O.A., Mazen M. Hypoglycemic and hypolipidemic activity of arginine containing bearberry leaves extract in insulin resistant rats. Медична та клінічна хімія. 2020. Т. 22. № 1. C. 5-10.

Перспективи створення нового лікарського засобу для корекції метаболічного синдрому на основі БАР мучниці звичайної листя / Н.Б. Чайка, О.М. Кошовий, Матар Мазен, А.Б. Кравченко, А.М. Ковальова, І.В. Кіреєв // Український біофармацевтичний журнал.2021. № 1(66). С. 46-52.

Research in phytochemical composition and hypoglycemic activity screening of the dry extracts from bearberry leaves / N. Chaika, M. Mazen, O. Koshovyi, G. Kravchenko, О. Goryacha, I. Kireyev, S. Kovalenko, R. Darmograi // «ScienceRise: Pharmaceutical Science». 2021. №3 (31). P. 42-50. (Scopus)

Arctostaphylos uva-ursi L. leaves extract and its modified cysteine preparation for the management of insulin resistance: chemical analysis and bioactivity / Kravchenko G., Krasilnikova O., Raal A., Mazen M., Chaika N., Kireyev I., Grytsyk A., Koshovyi O. Natural products and bioprospecting. 2022. 12(1), 30. (Scopus)

Спосіб одержання засобу з гіпоглікемічною та гепатопротекторною дією з листя мучниці звичайної з додаванням аргініну / Кошовий О. М., Кравченко Г. Б., Красільнікова О. А.,Чайка Н. Б., Матар Мазен (UA): патент на винахід C2 124042, Україна; заявл. 21.10.19; опубл. 07.07.21. Бюл. № 27, с. 4.

Спосіб одержання засобу з гіпоглікемічною та ліпотропною дією з листя мучниці звичайної з додаванням цистеїну/ Кошовий О. М., Кравченко Г. Б., Красільнікова О. А.,Чайка Н. Б., Матар Мазен (UA): патент на винахід C2 124043, Україна; заявл. 21.10.19; опубл. 07.07.21. Бюл. № 27, с. 4.

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