Behei N. Development of the composition, technology and research of tablets that affect the cardiovascular system

The thesis presents an experimental study of the development of the optimal composition, technology and research of a combined tablets based on amlodipine besylate and enalapril maleate with antihypertensive effect. A methodology of the development of solid dosage forms with amlodipine besylate and enalapril maleate has been suggested. The characteristics of active pharmaceutical ingredients and excipients have been presented. A study of the development of the optimal composition and technology of amlodipine tablets with enalapril for the treatment of arterial hypertension by the wet granulation method has been carried out. As a result, the composition of amlodipine tablets with enalapril has been theoretically and experimentally explained. A draft technological regulation has been developed and the critical parameters of the technological process for amlodipine tablets with enalapril has been substantiated. The project of methods of quality control of the studied tablets of amlodipine with enalapril using the method of high-performance liquid chromatography has been developed, scientifically substantiated and tested. Microbiological tests of the studied tablets have been carried out.