Sodomora O. Structural organization of the carotid sinus under the influence of monosodium glutamate in experimental setting

The thesis paper studies the peculiarities of changes in the structural organization of the carotid sinus of male albino rats under the influence of monosodium glutamate and following its withdrawal in experimental setting. The aim of the study was to establish peculiarities of structural organization of carotid sinus in the setting of monosodium glutamate oral consumption in an experiment. For the first time, a comprehensive morphological study of the carotid sinus was conducted and new morphometric data was obtained concerning the structural components of the carotid sinus included thickness of intima, media and adventitia of the carotid sinus vascular wall, relative square area of carotid glomus clusters as well as thickness of carotid glomus connective tissue stromal stripes of the male albino rats during the 8-week-long monosodium glutamate oral administration and 2 weeks following its withdrawal with preceding 4- and 8-week-long periods of consumption. The study of structural changes of the carotid sinus in albino rats during systematic daily consumption of monosodium glutamate and following its withdrawal has considerable practical value for the establishment of the character, degree and reversibility of monosodium glutamate-related alterations of the carotid sinus wall and carotid glomus, as well as for understanding the role of monosodium glutamate in the pathogenesis of morphologic changes that comprise the background for cerebral perfusion impairment. The results obtained are a morphological base for the development of new prevention and treatment methods when it comes to pathologic conditions that involve structural impairment of the carotid arteries related to monosodium glutamate intake in patients with atherosclerosis, increased body weight, lipid metabolism abnormalities and other comorbidities.