Yuriev S. Immunological features of pathogenesis, diagnosis and treatment of perennial rhinitis in patients with sensitization to house dust mites.

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0823U101593

Thesis Registration Form

0823U101593.pdf

Applicant for

Specialization

  • 222 - Медицина

08-01-2024

Specialized Academic Board

ДФ 26.003.115

Bogomolets National Medical University

Essay

The purpose of the study is to study the features of the clinical course, the functional state of the immune system, and the effectiveness of allergen-specific therapy (ASIT) in patients with IgE-dependent and IgE-independent forms of allergic rhinitis (AR) caused by sensitization to house dust mites (HDM). In the dissertation work, the molecular profile of sensitization to HDM was determined, and a comparative analysis of alternative methods of assessing hypersensitivity in people with an allergy to HDM was carried out. The features of the immune response and approaches to treatment in patients with different pathogenetic mechanisms of AR development – IgE-dependent and IgE-independent forms – have been determined. The effectiveness of the use of ASIT in patients with IgE-dependent form of AR has been scientifically substantiated and proven, and the accuracy of the personalized approach to its use has been proven. During the study, allergy pathology was verified in 112 patients according to the following clinical signs: 85 (75.9%) patients had complaints of periodic/constant sneezing, 77 (68.7%) - periodic rhinorrhea, 84 (75, 0%) – nasal congestion, 74 (66.1%) – itchy nose/eyes, 54 (48.2%) – rhinoconjunctivitis, 44 (39.3%) – dry skin, 29 ( 26.9%) – erythematous-squamous rashes on the skin of the upper limbs, upper chest, neck, etc. with itching, 25 (22.3%) – recurrent broncho-obstructive syndrome (BOS). Mild eosinophilia (from 0.6 to 1.5 G/l) was detected in the general blood test (CBC) in 22 (19.6%) persons. An increased number of eosinophils (from 17% to 75% in the field of view) was found in the smear-print of the nasal mucosa in 52 (46.4%) people. Persistent (year-round) AR, 31 (27.7%) people and intermittent (seasonal) AR, 29 (25.8%) people were most often diagnosed among the examined patients.

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Research papers

Yuriev, S. (2020). Assessment of the cytokine profile in patients with allergic rhinitis caused by sensitization to house dust mite. Immunology and Allergology: Science and Practice, (1), 25-31. https://doi.org/10.37321/immunology.2020.01-04 ISSN: 2707-1871

Marushko, I., Halushko , B., Yuriev , S., Hyshchak , T., & Moskovenko, E. . (2021). CLINICAL SIGNIFICANCE OF IgG ANTIBODIES IN THE DIAGNOSIS OF ALLERGIC CONDITIONS AND CONTROL OF ALLERGEN-SPECIFIC IMMUNOTHERAPY. Review. Medical Science of Ukraine (MSU), 17(4). https://doi.org/10.32345/2664-4738.4.2021.18

Rodinkova VV, Yuriev SD, Kryvopustova MV, Mokin VB, Kryzhanovskyi YM and Kurchenko AI (2022) Molecular Profile Sensitization to House Dust Mites as an Important Aspect for Predicting the Efficiency of Allergen Immunotherapy. Front. Immunol. 13:848616. doi: 10.3389/fimmu.2022.848616

Yuriev S, Rodinkova V, Mokin V, Varchuk I, Sharikadze O, Marushko Y, Halushko B, Kurchenko A. Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens. Clin Mol Allergy. 2023 Feb 3;21(1):1. doi: 10.1186/s12948-022-00182-z. PMID: 36737770; PMCID: PMC9898923.

Marushko YuV, Halushko BL, Yuriev CD, Hyshchak TV. (2022). Sensitization profile to house dust mite allergens in children with allergies in Ukraine. Modern Pediatrics. Ukraine. 6(126): 30-36. doi 10.15574/SP.2022.126.30. Article received: Jul 12, 2022. Accepted for publication: Oct 20, 2022.

Юр'єв С. Д. Алгоритм відбору пацієнтів з алергічним ринітом і сенсибілізацією до кліщів домашнього пилу для проведення алерген­імунотерапії / С. Д. Юр'єв, А. І. Курченко, Г. В. Федорук // Імунологія та алергологія: наука і практика. - 2019. - № 1. - С. 46-53. - Режим доступу: http://nbuv.gov.ua/UJRN/Ita_2019_1_7. ISSN: друковане - 2707-1871

"Юр’єв, С. Д., & КурченкоА, І. (2022). ОСОБЛИВОСТІ ІМУННОЇ ВІДПОВІДІ У ПАЦІЄНТІВ З ЦІЛОРІЧНИМ АЛЕРГІЧНИМ РИНІТОМ ТА СЕНСИБІЛІЗАЦІЄЮ ДО КЛІЩІВ ДОМАШНЬОГО ПИЛУ // AСТМА ТА АЛЕРГІЯ. - 2022. - 1–2. - С. 35-42. ISSN 2307-3373 DOI: 10.31655/2307-3373-2022-1-2-35-42"

ЗУБЧЕНКО С.О., ГАЙДУЧОК І.Г., ЮР`ЄВ С.Д., ЧОПЯК В.В. // ОЦІНКА КЛІНІЧНОЇ ЕФЕКТИВНОСТІ АЛЕРГЕНІМУНОТЕРАПІЇ У ПАЦІЄНТІВ З АЛЕРГІЧНИМИ ХВОРОБАМИ // ІМУНОЛОГІЯ ТА АЛЕРГОЛОГІЯ: НАУКА І ПРАКТИКА. 3-4'2020 // doi:10.37321/immunology.2020.3-4-08

Зубченко С. Порівняльний аналіз альтернативних методів діагностики профілю сенсибілізації пацієнтів західного регіону україни / С. Зубченко, В. Чоп’як, О. Колінковський, С. Юр’єв, О. Шарікадзе // Імунологія та алергологія: наука і практика. - 2019. - № 3. - С. 45-59. - Режим доступу: http://nbuv.gov.ua/UJRN/Ita_2019_3_7.

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Files

24-11- Дисертація Юр'єв С-Д- з електронним підписом остання версія.pdf

autoreferat-Анотація Юр'єв С-Д-.pdf

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