Kobeniak M.M. Morphological and functional features of large intestine tissues when suturing with different surgical threads in the experiment.
The scientific qualifying work presents a theoretical generalisation and a new solution to the actual scientific problem: to establish the dynamics of structural and functional changes in the perivascular region of the rabbit cecum when suturing with various surgical threads, including modified biologically active substances. The obtained results of complex morphological studies and their comparative analysis allowed us to determine the degree of morphological and functional changes in the structural components of the wall of the rabbit cecum in normal conditions and perivascular regions when using surgical sutures Vicryl and desmosin modified with L-arginine.
For the first time, a domestic monofilament surgical thread desmosin modified with the biologically active substance L-arginine was developed, and its advantages and prospects for use in surgical practice were substantiated at the morphological level.
For the first time, with the help of modern and adequate research methods and using a comprehensive methodological approach, a morphological analysis of the process of remodelling the structural components of the cecum wall in the perivascular area, was performed using different sutures, including those modified with L-arginine.
The understanding of the microscopic and submicroscopic restructuring of the structural components of the cecum wall in the perivascular region using different sutures, including those modified with L-arginine, has been expanded.
For the first time, microscopic, submicroscopic and morphometric changes were identified that reveal the features of reparative, compensatory-adaptive and degenerative processes in the perivascular area when using different suture materials, including those modified with L-arginine.
It has been determined for the first time that the degree of reparative processes in the perivulnar region of the cecum when using different sutures, including those modified with L-arginine, is characterised by stages and directly depends on the duration of the postoperative period and the presence of biologically active substances in the inflammation focus caused by the wound defect, which come directly from the surgical thread.
Key words of the dissertation: animals, morphology, morphometry, correlation analysis, digestive system, intestinal lymphoid tissue, intestinal wall, cecum, electron microscopy, haemomicrocirculatory bed, crypts, own glands, lymphoid epithelium, mucosa, surgical thread.
