Kilyeyeva O. Pharmacoeconomic Approaches to the Application of Cosmeceutical Agents for Complex Treatment and Prevention of Skin Diseases

Українська версія

Thesis for the degree of Doctor of Philosophy (PhD)

State registration number

0824U001408

Applicant for

Specialization

  • 226 - Фармація, промислова фармація

26-04-2024

Specialized Academic Board

ДФ 17.600.073

Zaporizhzhia State Medical and Pharmaceutical University

Essay

The dissertation is based on pharmacoeconomic approaches to the application of cosmeceutical products for complex treatment and prevention of skin diseases; marketing research on the current regulation of cosmeceutical products circulation in Ukraine, and international experience of EU countries; substantiation of organisational and economic approaches and the pharmacoeconomic evaluation of the application of cosmeceutical products for complex treatment and prevention of skin diseases. As a result of the conducted analysis of literary sources, data on the aetiology, pathogenesis, and modern approaches to the treatment of acne and rosacea have been summarised. The current regulatory framework that governs the circulation of Medicinal Cosmetic Products in Ukraine and abroad has been analysed. It has been demonstrated that there is a certain inconsistency in regulatory norms regarding the circulation of Medicinal Cosmetic Products and Cosmetic Products in Ukraine at present. It has been established that the issues of regulating the circulation of Medicinal Cosmetic Products and Cosmetic Products remain inconsistent across all countries where the production of both Medicinal Cosmetic Products and Cosmetic Products is established. A study was conducted on the state and current trends in the development of the market for solutions to dermatological pathologies, specifically acne and rosacea, which allowed identifying significant potential for its growth. An analysis of the current pharmaceutical market of cosmeceutical products for comprehensive treatment and prevention of skin diseases during puberty, middle age, mature age, and elderly age has been conducted. Through the study of the pharmaceutical market in Ukraine for the availability of medicinal products used for the treatment of skin conditions, specifically acne and rosacea, it has been determined that domestic medicinal cosmeceutical products hold the leading positions. Optimisation and further rationality of prescription schemes for cosmeceutical products in comprehensive treatment and prevention of skin diseases have been defined. Methodological approaches to conducting pharmacoeconomic studies using cosmeceutical products for the comprehensive treatment and prevention of acne and rosacea have been substantiated. A survey was conducted using a developed questionnaire for pharmaceutical professionals (pharmacists, pharmacist-interns, pharmacy assistants) in Zaporizhzhia, Dnipro, Mykolaiv, Kryvyi Rih, and Cherkasy cities. Based on the analysis of the collected data, a range of Medicinal Cosmetic Products that are in high demand among consumers and recommendations provided by pharmaceutical professionals for their use were determined. These products became the subject of further analysis to determine their competitiveness indicator. Research on the unified clinical protocols of primary, secondary (specialized), and tertiary (highly specialized) medical care Unified Clinical Protocols of Medical Care for the provision of pharmaceutical care for acne and rosacea has been conducted. Development of recommendations for the application of the method for calculating competitiveness, assortment stability, and solvency adequacy of cosmetic products containing azelaic acid for acne treatment; assessment of the quality of life of patients with rosacea and recommendations for the inclusion of certain cosmetic products in the list of essential pharmaceuticals.

Research papers

Кілєєва О. П., Бушуєва І. В. Космецевтичні засоби у комплексному лікуванні та профілактиці розацеа. Innovative solutions in modern science. 2016. Vol. 3, N 3. P. 25–36.

Кілєєва О. П., Бушуєва І. В. Догляд за жирною шкірою з застосуванням лосьйонів та гелів при лікуванні акне в комплексній терапії. Paradigm of knowledge. 2017. Vol. 3, N 23. P. 36–46.

Кілєєва О. П., Бушуєва І. В. Застосування лікарських косметичних засобів у комплесному лікуванні розацеа. Актуальні питання фармацевтичної і медичної науки та практики. 2018. Т. 11, №1 (26). С. 91–96. DOI: 10.14739/2409-2932.2018.1.123725.

Кілєєва О. П., Бушуєва І. В. Аналіз застосування лікарських косметичних засобів в комплексній терапії акне та розацеа в умовах амбулаторного лікування (на прикладі Запорізької області). Актуальні питання фармацевтичної і медичної науки та практики. 2019. Т. 12, № 3 (31). С. 334–338. DOI: 10.14739/2409-2932.2019.3.184212.

Кілєєва О. П. Маркетингові дослідження та фармакоекономічні аспекти лікарських косметичних засобів, що містять азелаїнову кислоту. Актуальні питання фармацевтичної і медичної науки та практики. 2019. Т. 12, № 1 (29). С. 91–96. DOI: 10.14739/2409-2932.2019.1.159164.

Bushueva I. V., Kileeva O. P. Combination therapy of acne (acne vulgaris) in patients of different age groups. Polish journal of science. 2019. N 21, Vol. 1. Р. 27–34.

Кілєєва О. П., Бушуєва І. В. Фармакоекономічні аспекти потенційного споживання лікарських косметичних засобів та косметичних засобів до складу яких входить саліцилова кислота. Health&Education. 2023. № 4. С. 108-116. DOI: 10.32782/health-2023.4.17.

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