Myshko N. Synthesis and properties of 2′-hydroxyhomoisoflavonoids and fsed chromene derivatives based on them

The relevance of the research work is based on the fact that natural hybrid molecules, which are formed by the intersection of various biosynthetic pathways, demonstrate a significant role in medicinal chemistry. As a result of the research, it was shown that the reaction of 2-hydroxyphenyl enamino ketones with 7-hydroxy-8-dimethylaminomethylcoumarins affords 2′-hydroxyhomoisoflavonoids based on coumarin core. Optimal reaction conditions were elaborated. The developed method opens a convenient approach to obtaining various new analogs of natural Sappanin-type homoisoflavonoids. The obtained results expand the possibilities of diversification of Sapanin-type homoisoflavonoids, the study of their biological properties and therapeutic potential.