The dissertation is devoted to the development of a new technology for the
extraction of Origanum vulgare, Hedera hibernica, Pelargonium sidoides using a
pneumatic press extractor and the introduction of the obtained extracts as
components in medicinal product "PELARMAT-PLYSHCH syrup" and
"PELARMAT-PLYSHCH tablets".
The paper considers various options for LRS extraction, in particular, modern
methods of dynamic extraction using a pneumatic press extractor to obtain extracts
containing a complex of biologically active substances (BAS) with proven
pharmacotherapeutic effect in respiratory tract diseases. The statistical data of the
Ministry of Health (MOH) of Ukraine regarding this group of diseases for the period
2019-2021 were analyzed and modern literature data on their treatment, including
the use of herbal preparations, were analyzed. As a result of the analysis, promising
medicinal plants whose phytochemical composition provides a therapeutic effect in
diseases of the respiratory system were selected, namely, common motherwort (O.
vulgare), leaves of common ivy (H. hibernica), roots of pelargonium (P. Sidoides)
and obtained from their extracts. Information on the chemical composition and
application of the studied raw materials has been processed. The analysis of literary
sources proves the expediency of using extracts of these plants as components for
the development of new complex medicines for the treatment of respiratory tract
diseases.
The pharmaceutical market of Ukraine and some European countries was
studied for herbal preparations, which include BARs of common motherwort (O.
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vulgare), leaves of common ivy (H. hibernica) and roots of pelargonium (P.
sidoides). On the pharmaceutical market of Ukraine, 18 preparations from the BAR
of St. John's wort, 29 preparations from the BAR of ivy leaves and 14 preparations
from the BAR of the roots of pelargonium are registered on the pharmaceutical
market of Ukraine. Most of these drugs are presented in the form of syrups (16
drugs) or liquid dosage forms (12 drugs) and tablets (10 drugs), the rest are extracts,
medicinal plant materials and ointments. According to the ATS classification, the
largest share of the assortment of preparations from St. John's wort belongs to drugs
of group N05, psycholeptics (38.46%) and drugs of group R05, drugs used in case
of coughs and colds (30.77%). The rest belong to groups G04 means used in urology
(23.08%) and G02 other gynecological means (7.69%). Most of the medicinal
products from the BAR of common ivy leaves and all from the roots of pelargonium
found on the Ukrainian pharmaceutical market belong to the group R05 means used
in the case of coughs and colds.
On the pharmaceutical market of Poland, there are 23 preparations containing
ivy leaves and 3 preparations from the roots of pelargonium ochitkovyka included
in the group of preparations that are used in case of coughs and colds. Preparations
with BAR of the common motherwort are currently not registered on this market or
the registration certificates have expired. On the pharmaceutical market of Austria
and Liechtenstein, there is one registered medicinal product containing motherwort
- this is a complex herbal tea for the treatment of asthma. There are 32 units of drugs
containing the BAR of ivy leaves, which are included in the R05 group, remedies
used in the case of cough and cold diseases and homeopathic drugs used for the
treatment of respiratory tract diseases, and 11 drugs with the BAR of the roots of
pelargonium are included in the group of drugs R05 . There are 8 preparations
containing ivy leaves on the Croatian pharmaceutical market and they belong to the
group of preparations used in case of coughs and colds. Preparations from the herb
of common motherwort and the roots of pelargonium are not available on this
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market.
