Dovbnia D. The search for antihypoxants and hypoglycemic agents among derivatives of 5-(2,4-, 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-thiones

Dissertation research occupies a key place among applied works in the field of pharmacy. This scientific work highlights the key aspects of the synthesis, study of physicochemical characteristics and search for new biologically active substances based on 5-(2,4-, 3,4-dimethoxyphenyl)-3H-1,2,4-triazole-3-thiones derivatives. The obtained compounds are characterized by low toxicity and high pharmacological activity, which may become substances for the development of promising medicines in the future. In the course of the research, zinc 2-((5-(3,4-di-methoxyphenyl)-3H-1,2,4-triazol-3-yl)thio)acetate was recommended for further preclinical and clinical study, as it showed high levels of glucose-lowering activity. For this substance, there was developed a laboratory method of synthesis, draft technical specifications for the final product, as well as «Quality Control Methods» for the substance to be used in the production of non-sterile medicines. Key words: 5-R-3H-1,2,4-triazole-3-thiones and their derivatives, оrganic synthesis, analysis, biological activity, hypoglycemic activity, antioxidant activity, molecular docking