Voskresens'ka O. The role of endocrine disruptors at the abnormalities of sexual maturation of girls-adults and the ways of their prophilactic.

The link between the spreding of abnormalities of sexual and physical maturation of 557 girls-adults and the level of contamination of region by endo-crine disrupters and was determinated. On the base of these data and the study of the level of sexual hormones in blood of girls-adults, the activity of the aromatase in placenta of women's from regions with different levels of endocrine dis-ruptors and the sexual matu-ration female rats during cronically treat-ment with inhibitors aromatase, was formulated a proposition about the maine role of violation of balance of androgens/estrogens due to inhibitions aromatase by endo-crine disrupters in the genesis abnormalities of sexual maturation of girls-adults. During the experiment at female rats and observation of girls for the first time was found that isoflavonoides soy capable to cover deficit of endogenous estrogen, reduce the effects of cronical inhibitions aromatase and to correct the abnormalities of sexual maturation and menstrual cycle of g irls-adults.