Lagodych T. Role of the nitric oxide in regulation of miocardial contractive activity under experimental hyperthrophy and hiperfunction of the heart.

Thesis is dedicated to stading the role of nitric oxide in contractive myocardial activity under experimental hyperthrophy and hiperfunction of the heart. It was shown that donors of nitric oxide - nitroglicerine and natrium nitroprusside induce decrease of contraktive function of the miocardium increase coronar flov of the isolated by Langendorf heart. Durable introdution on NO predecesso - L-arginine to the rats with coarctation of aorta bungs to significant increase of heart weight, its function, preserwation of contactive and powerproducing structures. Negative hronoinotrope dependency characteristic for the rats disappears under hyperfunction and hypertrophy. Once - thought introduction of nitroglicerine restores negative chronoinotrope dependency under condition of hyperfunction and hyperthrophy. Durable introdution of L-arginine transforms chronoinotrope dependency into arched. Revealed chenges in chronoinotrope reaction under miocardial hyperfunctiom and hyperthrophy are connekted with intra- and extracellular calcium - ions exchange.