Kondratieva O. Age aspect of the neurotransmitter mechanism of the formation of cognitive activity in conditions of thyroid dysfunction

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0421U100926

Thesis Registration Form

0421U100926.pdf

Applicant for

Kondratieva Olena Yuriyivna

Specialization

14.03.03 - Нормальна фізіологія

Date of defense

01-04-2021

Specialized Academic Board

Д 35.600.03

Danylo Halytsky Lviv National Medical University

Essay

Cognitive activity in thyroid dysfunction was studied in experiments on animals of three age groups. Experimental hyperthyroidism in juvenile and young rats caused an anxiolytic effect and improvement (in juveniles) or maintenance of spatial memory control in the Morris water labyrinth, accompanied by an increase in gamma-aminobutyric acid in the neocortex and gluteum. Anxiogenic effect and deterioration of cognitive activity were observed in older animals, which was accompanied by an excessive increase in the content of glutamate in the cortex and glycine in the hippocampus. Experimental hypothyroidism contributed to the formation of anxiogenic effect and deterioration of cognitive activity throughout ontogenesis

Thesis supervisor

Rodinsky Alexander Georgievych

Official opponents

Voronych-Semchenko Nataliia Mykolaivna
Vadziuk Stepan Nestorovych

Files

autoreferat-aref.doc

dis.doc

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