Stetseviat V. Thyroid status, metabolic processes and their gender features under conditions of iodine deficiency and insulin resistance in the experiment

In the dissertation the actual scientific and applied task on the establishment of mechanisms of change of a thyroid homeostasis, markers of a carbohydrate and lipid metabolism, a course of redox reactions in insulin-sensitive organs, antiradical defense, structural and metabolic changes of liver under conditions of insulin resistance on the background of fructose loading and iodine deficiency in the first and the second generation of animals, taking into account sexual dimorphism was resolved. Physiological, biochemical, histological, morphometric, statistical research methods were used in the scientific work. The practical value lies in the establishment of criteria for the differential diagnosis of insulin resistance and hypothyroidism in animals on the background of adequate iodine supply, pre- and postnatal iodine deficiency. The obtained data are informative about the physiological norm, iodine deficiency, insulin resistance and their combination.