Kuznyetsova O. The Role of the Endotoxin gramnegative microflora in the cytokine Regulation of the activity of Cellular Factors of nonspecific immune Protection, Fibrinolysis and Proteolisis

In experimets it has become possible to establish a consistent pattern of raising serum concentrations of interleukin - 1(( IL-1(), and the tumor necrosis factor ( (TNF() following splenectomy that occurs due to an increased functional activity of neutrophils and monocytes - macrophages, intensified fibrinolysis, proteolysis and lipoperoxidation and in case of simulating systemic endotoxinemia it is accompanied by a decreased blood content of proinflammatory cytokines a diminished activity of blood phagacytosing cells and inhibited plasma and tissue proteolysis. A disturbance of nonspecific immune defence in thymectomized rats are characterized by neutrophil diminished ability to generate active oxygen forms that are associated with a decrease of the serum IL-1( concentration. There occur changes of the cavital and mucous microflora of the small and large intestines in rats with experimental dysbacteriosis that are accompanied by a decrease of the serum levels of IL-1( and TNF(. A method of target correction for disturbances of cytokine regulation of nonspecific immune response has been substantiated pathogenetically under conditions of intestinal dysbacteriosis on the basis of studying the effect of bifiform and splenin on the composition and population level of the microflora, the blood content of IL-1( and TNF(