Zaltsman N. Neonatal Hypothyrosis and Hemostatic Disturbance: Pathogenetic Role of Heavy Metals

Reverse age gestational dependence of the blood thyroid hormone content in premature newborns with neonatal hypothyrosis was established in the clinical part of the research. In experiments it was demonstrated that under conditions of neonatal hypothyrosis the ability of the tissues of the heart, liver, kidneys and aorta to trap 125I-triiodothyronine and 3H-thymidine in the posterity of female rats which received low doses of the chlorous compounds of cadmium, thallium and plum-bum. Changes in the regulating system of the aggregate blood state are characterized by a primary activation of the thrombocytic-vascular hemostasis, chronometric hypercoagulation, suppression of the anticoagulating blood activity and enzymatic fibrinolysis that is associated with an increased intensity of lipid peroxidation. It was shown that there occurred a sharp inhibition of tissue fibrinolysisin the cardiac, hepatic and renal tissues in the posterity of female rats which received heavy metals at the time of pregnancy and (or) lactation. An early and prolonged use of triiodothyronine effectively resolves the complications of neonatal hypothyrosis: normalizes the pro- and antioxidant potentials, enzymatic fibrinolysis in the tissues of the heart, liver, kidneys.