Karlinska O. Clinical and pathogenetic aspects of myocardium remodulation in acute period of myocardium infarction

The purpose of the work was in optimization of the diagnosis of morphological and functional remodelling of myocardium at the patients with myocardial infarction and working our the methods of treatment of hemodinamyc disturbances and arrhythmiac wiht the use of inhibitors AСЕ, athenolol and amiodaron. There were examinate 205 patients. There was determined pathogenetic connection between myocardial remodelling of the heart and occuring electrophysiologycal changes of dispersia repolarisation of myocardium which are revealed in dispersion of the interval QT and its fragments may be used in diagnosis of electric nonstability of myocardium in patients in acute period of the disease and process of the following evolution of focal-necrotic changes. The increase unhomohenics of repolarisation directly depends on the degree of morphofunctional remodulation of the heart injury, lowering of EF, IM localization and lowering of diastolic function of the heart.