Hayduk A. Residual Liver Function and Methods of Its Regulation: experimental and clinical research

The dissertation comprises the experimental and clinical study of the Residual Liver Function (RLF), methods of its evaluation and its potential application as a prognostic marker in diffuse liver diseases. A phenomenology definition of RLF is formulated, experimentally justfied and discussed. An approach for the preservation and correction of RLF by means of complex protein-salt remedies Lactosorbal and Lactoprotein is proposed and studied in experimental and clinical conditions. RLF can be quantitatively evaluated by means of estimation of the endogenous intoxication level measured with LII, PT or MMP. The experimental studies reveal the correlation of the initial PT-, LII- and the MMP- values with the evolution of the liver function tests during the development of the experimental toxic hepatitis. Thus, the initial LII-, MMP- and PT-values predict the development of the diffuse liver disease. The saturation of the hepatocytes with the glycogen correspond to the endotoxemia level and functional liverstate, and thus can serve as morphological proof of RLF state.