Nazar B. Pharmaco-toxicology appraisal of Fenaron action.

Object of researches - determination of parameters of toxicodynamics and remote effects on infusoria, laboratory animals and poultry. The purpose of researches - to study toxicodynamics of borocin and to determine parameters of toxicity in acute and chronic researches on infusoria, mice, rats and poultry. To determine its cumulation, the degree of its mutagenic action and pharmacokinetical features of the acting substance of the preparation. Methods of the researches - pharmacotoxicological (acute and chronic toxicity, cumulation, pharmacokinetics, mutagenicity), hematological, biochemical and histological researches. The scientific discovering - it was only firstly studied toxicodynamics of borocin - a new antimicrobial preparation from the group of fluoroquinolone, it was also studied its toxical parameters in acute and chronic researches on laboratory animals and poultry. It was studied mutagenic action of borocin and its effects to cumulation in organs of rats and poultry. It was studied dynamics of any changes in coefficients of masses of inner organs, hematological and biochemical dates of blood of rats and young poultry during chronic toxical researches of the preparation. It was also studied histological structure of inner organs and process of regeneration in rats during prolong application of the preparation. It was determined kinetical charachteristics of the acting substance of the preparation. The degree of application - the results of toxicological researches have been taken in Technical Conditions for borocin and it was discovered and effermed the Directions for the given preparation usage during bacterial illnessis of poultry. Sphere (area) of usage - determination of non-dangerous effect of the preparation according to its "toxicity" in the studying process of toxicology and clinical pharmakology and borocin usage in practical veterinary medicine.