Ostapiuk A. The state of the protective systems of poultry in experimental chronic cadmium toxicosis and corrective factors

The object of research: experimentally simulated cadmium toxicosis in poultry and its prevention. The purpose of research: to determine the peculiarities of the course of chronic cadmium toxicosis in poultry and develop schemes for its prevention and treatment. Research methods: hematological (morphological, biochemical); pharmacotoxicological (acute and subacute toxicity); clinical (anamnesis, clinical examination of animals); statistical (processing of research results). Scientific novelty: New aspects of the pathogenesis of cadmium toxicosis in poultry are revealed. In particular, the influence of Cadmium on the state of the protective systems of the body of laying hens is established. The effect of milk thistle, methiphen, and silimevit on the protective systems of chickens was studied for the first time. The pharmacodynamics of milk thistle, methiphene, and silimevit on the immune and antioxidant status of laying hens under cadmium loading were studied. The use of the supplement "Silimevit" has advantages over the use of milk thistle beaches and methiphen in the previous negative effects of Cadmium on the body of poultry. It was found that the treatment of supplements "Silimevit" reduces the adverse effects of Cadmium on the body of chickens, normalizes, under these conditions, the morphological and biochemical parameters of the blood, antioxidant and immune status of experimental birds. The expediency of using Silimevit additives for laying hens for cadmium loading has been scientifically substantiated and experimentally confirmed. Received TС of Ukraine in addition to "Silimevit." Proposed: Based on the conducted research, the scientific and practical idea about new aspects of pathogenetic mechanisms of the simulated cadmium toxicosis in poultry is formed. A practical scheme of treatment of laying hens, prevention of cadmium toxicosis is developed. It was found that the supplement "Silimevit," which was used in laying hens with feed for 30 days to prevent the toxic effects of Cadmium, significantly reduces its adverse effects, and thus decreases its level in poultry, which is expressed in stabilizing biochemical parameters and strengthening protective body systems. Implemented: The results of research implemented in the educational process in the discipline "Veterinary Pharmacology," "Clinical Veterinary Pharmacology," and "Veterinary Toxicology" of the universities and for students of the Faculty of Postgraduate Education.