Derkach I. Scientific and experimental substantiation of the pharmacological activity of Iron(IV)

The dissertation is devoted to the study of the pharmacological and toxicological properties of Iron(IV) clathrochelate as a unique compound containing Iron in a rare high valence form – IV. The results of determining the pharmacological activity, preclinical and clinical studies of Iron(IV) with the aim of creating national anti-anemic drugs are presented in the dissertation. The obtained results confirm that Iron(IV) clathrochelate corresponds to the III class of danger, according to the classification of chemical substances by the degree of danger, and to the IV class and the degree of toxicity "low-toxic substances", according to the classification of substances by toxicity. It has been experimentally proven that Iron(IV) clathrochelate has weak cumulative properties, and the cumulation coefficient is 6.88 units. Iron(IV) clatrochelate did not have an irritating effect on the skin and conjunctiva of rabbits, did not cause an allergic reaction in sensitized guinea pigs. The high anti-anemic efficiency of Iron(IV) clathrochelate was established by its clinical studies on suckling piglets, which were injected intramuscularly on the 2nd day of life in a dose of 2 ml of a 10% solution of the investigated compound, after intramuscular injection of 10% solution of Iron(IV) clathrochelate on rheopolyglucin to pregnant sows in a dose of 10 ml 14 and 7 days before the expected farrowing, and after intramuscular administration to pregnant sows of 10% Iron(IV) clathrochelate solution on rheopolyglucin in a dose of 10 ml and cyanocobalamin solution in a dose of 500 mkg 14 and 7 days before the expected farrowing. The content of Iron in the colostrum of sows that were intramuscularly injected solutions of Iron(IV) clatrochelate and cyanocobalamin on the 14th and 7th days before farrowing was probably higher than the indicators in the control in all periods of the experiment.