Красільнікова О. The role of thyroid hormones in regulation of phospho-inositide metabolism in rat liver during ageing

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U001934

Thesis Registration Form

0403U001934.pdf

Applicant for

Specialization

  • 03.00.13 - Фізіологія людини і тварин

14-05-2003

Specialized Academic Board

Д 64.051.17

Essay

Method of investigation: radioimmunologycal, chroma-tographic and radioisotope methods. Results, novelty: it was found that the content of polyphosphoinositides and their metabolism have been found to decrease with age. It was established that the phosphatidylinositol and poly-phosphoinositides synthesis in the liver of rats of different age is regulated by the thyroid state of organism. In vitro thyroxine stimulates phosphatidylinositol-4,5-bisphosphate hydrolysis in hepatocytes which is accompanied by accu-mulation of second messengers. In isolated liver cells thy-roxine activates protein kinase C-dependent resynthesis of phosphatidylinositol-4,5-bisphosphate. Field of implementa-tion: fundamental and clinical endocrinology

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