Dovbonos T. Hemorrhagic transformation of cerebral infarct: clinical manifestation, diagnosis and treatment

The main types of hemorrhagic transformation of cerebral infarct are established in the work. Enlarged risk of intrainfarct types of HT is found at the presence of arterial hypertension, atrial fibrillation, diabetes mellitus or stress hyperglycemia, and their complex effect; mixed types of HT ? at the presence of these factors and disturbances of coagulation hemostasis. Perfusion mechanisms dominate in cases of arterial hypertension, cardioembolic genesis of stroke primarily causes reperfusion injury; diabetes mellitus or stress hyperglycemia ? metabolic lesion of vascular wall. Pronounced neurological deficit associates with large supratentorial lesions at intrainfarct types of the secondary hemorrhage. Severity of clinical state of patients with mixed types mainly depends on massive bleeding. Systemic-cerebral hemodynamic disturbances have some particularities at different types of HT. Worked out differentiated method of therapy of HT which depends on the type of hemorrhagic complications is pathogenically substantiated and individualized, what let enlarge part of patients with full regress of neurological deficit and light neurological disturbances, and decreases percentage of fatal cases.