Felipova E. Research of changes of cardio-vascular system and peroxides oxidation of lipoids in heavy physical load and its correction

The dissertation is dedicated to the research of changes of cardio-vascular system and peroxides oxidation of lipoids in heavy physical load and grounds of the possible use of quercetin bioflavonoid for the purpose of their correction. The indices of the variability of cardiac rhythm, as determined, are sensitive markers of the functional state of the organism in adapted sportsmen. They allow describing quantitatively the activity of vegetative nervous system as the system of adaptation to heavy physical load. The contractile function of the left ventricle in adapted sportsmen characterized by authentic decrease of the final-diastolic size of the left ventricle, increase of the stroke volume cardiac output fraction, contraction degree of the left ventricle during conducting tests with physical load; that means the better contractile function of the left ventricle in comparison with un adapted sportsmen and may be used in order to diagnose functional state of the organism in sportsmen. Constant heavy physical loads in sportsmen do not increase to a marked degree the mass of the left ventricle myocardium (P<0,05). The immune status impairments are present in 70 % sportsmen in heavy physical load, which are characterized by T-lymphopenia, rising of the level of the circulating immune complexes, mainly owing to the most by lowering of immune serum globulin level. Substantial increase of level of peroxides oxidation of lipoids, against a background of oppression of antioxidant protection, and accumulation of "middle molecules" in blood take place as well, which is confirmed by the deficiency of vitamins with antioxidant properties. Prescription of bioflavonoid quercetin in adapted sportsmen in heavy physical loads has positive influence on the state of the immune system, peroxides oxidation of lipoids and antioxidant protection.