Kuzmis A. Age related particularities of rat connective tissue response to the effects of exogenous and endogenous factors

Objective is the link between connective tissue functional properties and collagen metabolism. Purpose is to determine age related and organ particularities of connective tissue response under the influence of ?-irradiation, pain related emotional stress, mechanical load and temperature. Methods of research are emotional stress simulation, radioisotope methods, fractional extraction, ionometry, fluorometry and analytical determination of amino acids. It was determined that a common response exists in connective tissue to various influences - intensification in collagen synthesis and break-up with decrease in its processing. Changes in visco-elastic properties of connective tissue are due to particular influence of each of the factors on collagen metabolism. It was determined that a correlation exists between a decrease with age in mechanical strain causing the cell response in connective tissue and increase in rigidity of tissue. Sphere of application is gerontology, traumatology and orthopedeady,adaptational physiology.