Reznichenko A. Optimizationof surgical treatment hyperplastie diseases of a thyroid gland by correction tiroxin-conditional immunological disbalance.

. Object of the study: Surgical diseases of the thyroid gland (toxic, nodular, euthyroid goiter, chronic autoimmune thyroiditis). Purpose of the study: To improve the results of surgical treatment. Methods of the investigation: general clinical, biochemical, immunological, statistical (Student's method). Practical significance of the obtained results: New is the study of pathogenetic significance of antibodies to native DNA in pa-tients with hyperplastic diseases of thyroid gland as well as thy-roxin-dependent functional activity of lymphocytes. A method of fibronectin-replacement therapy consisting in the use of infusions of heparinized freshly-frozen plasma of the same group, was worked out and introduced into practice. It was proved that the use of fibronectin-replacement therapy in early post-operative period in patients with toxic goiter provides reduction of clinical manifestations of post-operative thyrotoxicosis. Novelty: The finding of the research suggest that the patients with hyperplasticdiseases of the thyroid gland develop disbalance in the system of cellular immunity before the surgery, it aggravates considerably in the early post-operative period. For the first time, the changes in plasma fibronectin amount and its cryoperceptive activity as well as the influence of this glycoproteid on hormone-(thyroxin, thymalin)-immune associations were studied in the process of surgical treatment. The changes of the amount of antibodies to native DNA in patients with hyperplastic diseases of the thyroid were in-vestigated. The influence of thyroxin on the stability of lymphocytes to lympholytic activity action of corticosteroids was revealed. For the first time, positive influence of fibronectinreplacement therapy on the course of early post-operative period in toxic goiter was shown. This was characterized by reduction of manifestations of post-operative thyrotoxicosis on the first day in the abdominal cavity and changes in the organism's immune reactivity. Degree of introduction: the findings of the research were introduced into the clinical practice of City Clinical Hospital No. 7 (Simferopol) and teaching process of Surgery department No. 2 of Crimean State medical University named after S.I. Georgievsky. Sphere of application: Medicine, surgery.