The dissertation is devoted to a problem of optimizing diagnosis and tactics of treatment of the patients with atypical forms of brain stroke of ischemic character. 110 patients with atypical course of ischemic stroke have been examined as well as 30 patients of control groupe, which included the patients with "classical" course of ischemic stroke. The patients with atypical course of ischemic stroke were divided into the following subgroups: 41 patients (37.3 %) - with pseudotumor stroke (PTS), 35 patients (31.8 %) - with hemorrhagic infarction (HI), 26 patients (23.6 %) - stroke with non-visualized foci (SWNF), 8 patients (7.3 %) - with "mirror" stroke (MS). The diagnosis of atypical forms was proved through clinical survey, taking anamnesis data, realization of additional methods of research (ACT, МRI, ТCD). For inspection, the patients were selected, whose clinical picture did not present absolutely typical syndroms, which arise in developing "classical" forms of ischemic stroke. For clinical picture of the patients with PPI the most inherent were syndroms ICH and convulsive, in rather smaller quantity of supervision - mental disorders. The patients with HI had - prevailed ICH and convulsive syndromes. The feature of clinical picture of the patients with HI presented high percentage of meningeal syndrome, and rather small quantity of mental disorders. The patients with SWNF had - ICH syndromes and mental disorders, much smaller quantity of convulsive syndromes, at the same time, the syndrome of static-dynamic disorders was higher than in the patients with other atypical forms. The patients with MS had the frequency of ICH syndromes occurrence, mental disorders, meningeal and convulsive disorders in regular high intervals with a frequency of 50 % - 75%. It has been established that the absence of heart attack on ACТ, МRI is not the proof of stroke absence. Increased frequency of revealed symptoms at the development of atypical forms of ischemic strokes (intracranial hypertension, convulsive attacks, mental disorders) is noted in case, when ischemic focus is located in the limits of more than one brain portion (two and even three). The analysis of carried out TCD has found out a combined lesion of several cerebral vessels, which has resulted in maintenance of chronic reduction perfusion of brain tissue even before the development of ischemic stroke. The analysis of optimization of treatment of the patients with atypical forms of ischemic brain stroke was carried out.