Tuchinska M. Dose-dependent influence of angiotensin-converting enzyme inhibitors and beta- adrenoblockers on endothelium functional state and myocardial remodeling in patients with previous myocardial infarction.

3. Object of investigation: patients that have ischemical heart disease with myocardial infarction in anamnesis. The aim of investigation: to increase the effect of the treatment of chronic heart failure in patients that had myocardial infarction on the base of study the influence of different doses of the ACE inhibitors and beta-blockers on the functional condition of endothelium and the process of myocardial remodeling. Methods of investigation: Functional condition of endothelium was determinate by the level of endothelium-1, cycling 3, 5 - guanisinmonophosphate, stabie metabolite of thromboxan TxB2, stable metabolite of prostacycline, myocardial function was investigated by the data's of EchoCG, 6 minutes walk test, lipid spectrum was established by the level of LPHT, LPLT, LPVLT, cholesterol, triglyceride, peroxids lipid oxidation and system of enzyme antioxidative defence was determinate by the level of malone dialdehyde, dien conjugate, SH-groups. Mathematical and statistic methods we've used toestimate the authentic divergence. Theoretical and practical results: Proved the purpose of taking into account the doze-dependent effects of ACE inhibitor - lizinopril and beta-blocker - carvedilol for choosing the tactics of their prescription. The differential ways of using this drug in dependence on the function of endothelium, indexes of peroxide oxidation and intracardiale hemodynamics are suggested. The extent of introduction: AMS of Ukraine introduces the results of the investigation to the work of therapeutical and cardiological departmens of clinics of Kharkov, Sumy and clinic of the Institute of Therapy. Sphere of application: medicine, cardiology.