Nyzhegorodtseva O. Endothelium-dependent Vasodilatation, Tumor Necrosis Factor-a in different Structural and Functional Types of Hypertensive Heart.

Object of the study:hypertensive patients Purpose of the study: research of diagnostic and prognostic criteria for hypertensive myocardium remodelling and different types of Left ventricular geometry with consideration of functional status of vascular endothelium a degree of influence of the proinflammatory cytokine and circadian patterns. Methods of the investigation: Structural-functional parameters of heart were diagnosed by ultrasound method. Content of stable NO metabolites level, cGMP levels and TNF-a concentration were measured by immunoenzyme method. 24-hour blood pressure profile was established by ambulatory blood pressure monitoring. Theoretical and practical results: The following studies substantiated expediency to determine content of NO production, cGMP concentration and TNF-a level as the factors which expose risk of development heart changes in hypertension and prevent complications. The measurement of these indices may be served as a diagnostic criterion of disease weight and raisesquality of diagnostic to prescribe adequate treatment with due regard individual feature of each patients. Novelty: Disbalance and functional disorders of endothelial system, cellular and intercellular interaction are detected in hypertensive patients. The relationship between changes of functional state of NO-system, TNF-a and hemodinamic parameters with hypertensive heart is fixed. Degree of introduction:the results of the research were introduced into the work of therapy departments of hospital No. 11 (Kharkiv), Losivsca territorial polyclinic (Kharkiv region). Methodical recommendations are published ("Modern aspects of diagnostics, prognosis and treatment of hypertensive heart" and "Ambulatory blood pressure monitoring for diagnostics of hypertension complications and individual treatment"). Sphere of application: medicine, therapy and cardiology departments.