Devjatkova U. Adrenergic Reactions State of White Rats with Different Thyroid Status at Cold Adaptation

Analysis of different adrenergic reactions state was performed. It was found that experimental mild hyperthyroidism imitated the state of cold adaptation but thyrotoxicosis and athyroidism caused damage to thermoregulatory system of an organism. Authors presented the evidences that the ability to modulate all main indices of cold calorigenesis formed the basis of noradrenaline and triiodothyronine thermoregulatory effects. It was found that repeated injections of noradrenaline, cold adaptation and experimental hyperthyroidism led to similar changes in ?1-adrenergic reaction.The athyroidism and thyrotoxicosis resulted in quite the opposite changes in ?1-adrenergic reactions. Based on the data obtained the authors came to a theoretical conclusion that sympathoadrenal system and thyroid gland hormones play an important role in mechanisms of homothermy maintenance which are mediated via adrenoreceptors and regulated by thyroid hormones.