Mandryk Y. The role of М1-cholinergic, D2-dophaminergic receptors and L-Са2+ channels in regulation of gastric secretion, blood flow and mucosal defense

The dissertation is devoted to defining special features of the gastric secretion, mucosal blood flow and cytoprotection in gastric mucosa in conditions of independent and simultaneous blockade of М1-cholinergic receptors (М1-ChR), D2-dofaminergic receptors (D2-DR) and L-Са2+ channels of intact animals and under ethanol action. We noticed a sharp slowdown of acid production, and decreasing NO level in conditions of М1-ChR inhibition under ethanol action. It was proved the role of peripheral D2-DR in regulation of basal gastric secretion. A multiple regulatory effect of simultaneous blockade of D2-DR and L-Са2+ channels or М1-ChR on parietal and main cells and mucosal blood flow level was revealed. It was shown, that under the simultaneous inhibition of М1-ChR and L-Са2+ channels take place the changes in lipid peroxidation in liver and pancreas.